abstract：:Previously we reported that several microRNAs (miRNA) are upregulated following experimentally induced traumatic brain injury (TBI) using both in vivo and in vitro approaches. Specific miRNAs were found to be sensitive to therapeutic hypothermia and may therefore be important targets for neuroprotective strategies. In...

journal_title：Brain research

authors： Truettner JS,Motti D,Dietrich WD

更新日期：2013-10-02 00:00:00

abstract：:Contradictory results have been reported with regard to the effects of various models of hepatic encephalopathy on the blood-brain barrier (BBB) permeability, which may be due partly to the use of brain concentrations of BBB markers without attention to their peripheral pharmacokinetics. The purpose of the current stu...

journal_title：Brain research

authors： Shaik IH,Miah MK,Bickel U,Mehvar R

更新日期：2013-09-19 00:00:00

abstract：:The endocrine disruptor Bisphenol-A (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects. The effects of BPA exposure during early organizational periods of development have been well documented. The current study focuses on the effects of short term, low-dose BPA exposure on anxiety, s...

journal_title：Brain research

authors： Diaz Weinstein S,Villafane JJ,Juliano N,Bowman RE

更新日期：2013-09-05 00:00:00

abstract：:The family of EF-hand calcium binding proteins is composed of more than 250 members. In search for other neuronal markers, we studied the expression pattern of Necab-1, -2 and -3 in the Ammons horn of adult mice at the gene- and protein levels using in-situ hybridization and immunohistochemistry. The genes for the thr...

journal_title：Brain research

authors： Zimmermann B,Girard F,Mészàr Z,Celio MR

更新日期：2013-08-28 00:00:00

abstract：BACKGROUND:Inflammatory damage aggravates the cerebral ischemic pathological process and may pave a new way for treatment. Bicyclol has been proved to elicit a series of biologic effects through its anti-inflammatory property in treating hepatitis and hepatic ischemic/reperfusion injury. Whether this protective effect ...

journal_title：Brain research

authors： Zhang J,Fu B,Zhang X,Chen L,Zhang L,Zhao X,Bai X,Zhu C,Cui L,Wang L

更新日期：2013-08-28 00:00:00

abstract：:The prefrontal cortex (PFC) plays a central role in preparatory and anticipatory attentional processes. To investigate whether subregions of the PFC play differential roles in these processes we investigated the effect of focal lesions to either lateral prefrontal (lateral PFC; n=11) or orbitofrontal cortex (OFC; n=13...

journal_title：Brain research

authors： Funderud I,Løvstad M,Lindgren M,Endestad T,Due-Tønnessen P,Meling TR,Knight RT,Solbakk AK

更新日期：2013-08-21 00:00:00

abstract：:How general anaesthetic drugs cause unconsciousness is a topic of ongoing clinical and scientific interest. It is becoming increasingly apparent that they disrupt cortical information processing, but the effects appear to depend on the spatial scale under investigation. In this study we investigated whether the intrav...

journal_title：Brain research

authors： Voss LJ,Baas CH,Hansson L,Li D,Sleigh JW

更新日期：2013-08-14 00:00:00

abstract：:Some occluded arteries of acute ischemic stroke (AIS) patients are not recanalized, even if thrombolytic therapy is performed. Considering such clinical settings, we examined the potential cerebroprotective efficacy of TAK-937, a novel cannabinoid receptor agonist, in young adult and aged rats with a permanent middle ...

journal_title：Brain research

authors： Murakami K,Suzuki M,Suzuki N,Hamajo K,Tsukamoto T,Shimojo M

更新日期：2013-08-14 00:00:00

abstract：:This study was done in urethane anesthetized, ovariectomized (OVX) female rats that were either implanted or not implanted with silastic capsules containing17β-estradiol (E2) to investigate the effect of systemic changes in E2 on the discharge rate of subfornical organ (SFO) neurons that projected to supraoptic nucleu...

journal_title：Brain research

authors： Ciriello J,Roder S

更新日期：2013-08-14 00:00:00

abstract：:This ERP study explores the brain's response to the manipulation of motor compatibility in action-related language. In Experiment 1 participants read sentences in which a protagonist performed two different manual actions either simultaneously or consecutively (e.g. While/after cleaning the wound he unrolled the banda...

journal_title：Brain research

authors： Santana EJ,de Vega M

更新日期：2013-08-14 00:00:00

abstract：:The phenomenon whereby the relative timing between presynaptic and postsynaptic spiking determines the direction and extent of synaptic changes in a critical temporal window is known as spike timing-dependent synaptic plasticity (STDP). We have previously reported that STDP profiles can be classified into two types de...

journal_title：Brain research

authors： Kondo M,Kitajima T,Fujii S,Tsukada M,Aihara T

更新日期：2013-08-14 00:00:00

abstract：:The default mode network (DMN) is characterised by coherent very low frequency (VLF) neural oscillations in the resting brain. The attenuation of this activity has been demonstrated following the transition from rest to performance of a broad range of cognitive goal-directed tasks. Whether the activity of resting stat...

journal_title：Brain research

authors： Hsu CF,Broyd SJ,Helps SK,Benikos N,Sonuga-Barke EJ

更新日期：2013-08-02 00:00:00

abstract：:Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions...

journal_title：Brain research

authors： Rutherford NJ,Lewis J,Clippinger AK,Thomas MA,Adamson J,Cruz PE,Cannon A,Xu G,Golde TE,Shaw G,Borchelt DR,Giasson BI

更新日期：2013-08-02 00:00:00

abstract：:Using a well-established model of binge-like ethanol treatment of rat pups on postnatal days (PD) 4-9, we found that maturation of GABAA receptor (GABAAR) miniature postsynaptic currents (mPSCs) was substantially blunted for medial septum/diagonal band (MS/DB) neurons in brain slices on PD 11-16. Ethanol reduced mPSC ...

journal_title：Brain research

authors： Wang H,DuBois DW,Tobery AN,Griffith WH,Brandt P,Frye GD

更新日期：2013-07-03 00:00:00

abstract：:Sex differences in cocaine's mechanisms of action and behavioral effects have been widely reported. However, little is known about how sex influences intracellular signaling cascades involved with drug-environment associations. We investigated whether ERK/CREB intracellular responses in the mesocorticolimbic circuitry...

journal_title：Brain research

authors： Nygard SK,Klambatsen A,Hazim R,Eltareb MH,Blank JC,Chang AJ,Quinones-Jenab V,Jenab S

更新日期：2013-07-03 00:00:00

abstract：:Maternal infection during pregnancy is associated with an increased risk of neurodevelopmental injury. Our aim was to investigate whether prenatal immune challenge could alter susceptibility to seizure-induced brain injury in adulthood. Pregnant Wistar rats were injected intraperitoneally with lipopolysaccharide (LPS)...

journal_title：Brain research

authors： Yin P,Liu J,Li Z,Wang YY,Qiao NN,Huang SY,Li BM,Sun RP

更新日期：2013-06-26 00:00:00

abstract：:To facilitate the study of the CaMKIIα function in vivo, a CaMKIIα-GFP transgenic mouse line was generated. Here, our goal is to provide the first neuroanatomical characterization of GFP expression in the CNS of this line of mouse. Overall, CaMKIIα-GFP expression is strong and highly heterogeneous, with the dentate gy...

journal_title：Brain research

authors： Wang X,Zhang C,Szábo G,Sun QQ

更新日期：2013-06-26 00:00:00

abstract：:The contribution of opioid receptors in the nucleus accumbens to contextual and auditory fear conditioning was examined. Impairment in contextual fear conditioning was found when training occurred under accumbal infusions of the opioid receptor agonist morphine in a dose-dependent and receptor specific fashion, only w...

journal_title：Brain research

authors： Iordanova MD,Haralambous T,McNally GP,Westbrook RF

更新日期：2013-06-23 00:00:00

abstract：:Beta-amyloid peptide (Aβ) has a causal role in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that Aβ can disrupt excitatory glutamatergic synaptic function at synaptic level. However, the underlying mechanisms remain obscure. In this study, we recorded evoked and spontaneous EPSCs in hippoca...

journal_title：Brain research

authors： Yao W,Zou HJ,Sun D,Ren SQ

更新日期：2013-06-17 00:00:00

abstract：:Alzheimer's disease (AD) classically presents with gray matter atrophy, as well as feature significant white matter abnormalities. Previous evidence indicates the overall burden of these pathological changes continues to advance as the disease progresses. The aim of this study was to investigate whether pathological a...

journal_title：Brain research

authors： Kitamura S,Kiuchi K,Taoka T,Hashimoto K,Ueda S,Yasuno F,Morikawa M,Kichikawa K,Kishimoto T

更新日期：2013-06-17 00:00:00

abstract：:The neuroprotection research in the last 2 decades has witnessed a growing interest in the functions of estrogens as neuroprotectants against neurodegenerative diseases including stroke. The neuroprotective action of estrogens has been well demonstrated in both in vitro and in vivo models of ischemic stroke. However, ...

journal_title：Brain research

authors： Liu R,Yang SH

更新日期：2013-06-13 00:00:00

abstract：:17β-estradiol (E2 or estrogen) is an endogenous steroid hormone that is well known to exert neuroprotection. Along these lines, one mechanism through which E2 protects the hippocampus from cerebral ischemia is by preventing the post-ischemic elevation of Dkk1, a neurodegenerative factor that serves as an antagonist of...

journal_title：Brain research

authors： Scott EL,Brann DW

更新日期：2013-06-13 00:00:00

abstract：:Affective disorders and memory impairments precede the classical motor symptoms seen in Parkinson's disease (PD) and the currently approved antiparkinsonian agents do not alleviate the non-motor symptoms as well as the underlying dopaminergic neuron degeneration. On the other hand, there is increasing evidence that in...

journal_title：Brain research

authors： Castro AA,Wiemes BP,Matheus FC,Lapa FR,Viola GG,Santos AR,Tasca CI,Prediger RD

更新日期：2013-06-04 00:00:00

abstract：:It is now well documented that optogenetics brings to neuroscience a long sought-after foothold to study the causal role of millisecond-scale activity of genetically or anatomically defined populations of neurons. Progress is rapid, and, as evidenced by the work collected in this Special Issue, the possibilities of wh...

journal_title：Brain research

authors： Smith KS,Graybiel AM

更新日期：2013-05-20 00:00:00

abstract：:A large body of evidence shows that methamphetamine (METH) causes sustained damage to the brain in animal models and human METH users. In chronic users there are indications of cognitive and motor deficits. Striatal neuropeptides are in a position to modulate the neurochemical effects of METH and consequently striatal...

journal_title：Brain research

authors： Afanador L,Mexhitaj I,Diaz C,Ordonez D,Baker L,Angulo JA

更新日期：2013-05-13 00:00:00

abstract：:While moderate calorie restriction (CR) in the absence of malnutrition has been consistently shown to have a systemic, beneficial effect against aging in several animals models, its effect on the brain microstructure in a non-human primate model remains to be studied using post-mortem histopathologic techniques. In th...

journal_title：Brain research

authors： Sridharan A,Pehar M,Salamat MS,Pugh TD,Bendlin BB,Willette AA,Anderson RM,Kemnitz JW,Colman RJ,Weindruch RH,Puglielli L,Johnson SC

更新日期：2013-05-01 00:00:00

abstract：:In order to identify the neurochemical alterations in motor associated subcortical nuclei, and enhance our understanding of neurophysiology of progressive reduction in fine motor control with aging, the metabolic changes in striatum and cerebellar cortex in SD rats along with aging were investigated using a metabonomi...

journal_title：Brain research

authors： Zhang X,Wu J,Liu H,Zhang X

更新日期：2013-04-24 00:00:00

abstract：:Brain iron overload has a detrimental role in brain injury after intracerebral hemorrhage (ICH). Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iron transport. The present study investigated changes in LCN2 expression after ICH and the role of iron in those changes. Male Sprague-Dawley rats...

journal_title：Brain research

authors： Dong M,Xi G,Keep RF,Hua Y

更新日期：2013-04-10 00:00:00

abstract：:The neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor are members of the endogenous opioid peptide family. In mammals N/OFQ modulates a variety of biological functions such as nociception, food intake, endocrine, control of neurotransmitter release, among others. In the molluscs Cepea nemoralis and Helix as...

journal_title：Brain research

authors： León-Olea M,Miller-Pérez C,Sánchez-Islas E,Mendoza-Sotelo J,Garduño-Gutiérrez R,de Gortari P,Amaya MI

更新日期：2013-04-10 00:00:00

abstract：:As life spans increased, neurodegenerative disorders that affect aging populations have also increased. Progressive neuronal loss in specific brain regions is the most common cause of neurodegenerative disease; however, key determinants mediating neuron loss are not fully understood. Using a model of mitochondrial mem...

journal_title：Brain research

authors： Nam MK,Shin HA,Han JH,Park DW,Rhim H

更新日期：2013-04-10 00:00:00

abstract：:Chronic vitamin B12 (cobalamin) deficiency in the mammalian central nervous system causes degenerative damage, especially in the spinal cord. Previous studies have shown that cobalamin status alters spinal cord expression of epidermal growth factor (EGF) and its receptor in rats. Employing a mouse model of cobalamin-d...

journal_title：Brain research

authors： Mutti E,Lildballe DL,Kristensen L,Birn H,Nexo E

更新日期：2013-03-29 00:00:00

abstract：:Fluoxetine is widely used for the treatment of depression. We examined the action of fluoxetine on cloned Kv4.3 stably expressed in CHO cells using the whole-cell patch-clamp technique. Fluoxetine did not significantly produce a reduction in the peak amplitude of Kv4.3, but increased the rate of current inactivation i...

journal_title：Brain research

authors： Jeong I,Choi JS,Hahn SJ

更新日期：2013-03-15 00:00:00

abstract：:Estrogen receptor α (ERα) isoforms with complex types of alternative splicing are naturally present in the human brain and may affect canonical receptor signaling. In the present study we investigated transcriptional activity of common ERα splice variants from this group with different molecular defects: MB1 (intron r...

journal_title：Brain research

authors： Ishunina TA,Sluiter AA,Swaab DF,Verwer RW

更新日期：2013-03-15 00:00:00

abstract：:α-Synuclein (α-syn) and oxidative stress play pivotal roles in the pathogenesis of Parkinson's disease (PD). However, the mechanisms underlying the interaction between α-syn and oxidative stress remain poorly understood. The present study provides evidence to suggest that the nuclear translocation of α-syn increases d...

journal_title：Brain research

authors： Zhou M,Xu S,Mi J,Uéda K,Chan P

更新日期：2013-03-15 00:00:00

abstract：:Headache medicine is primarily dependent on patients' subjective reports of pain, which are assessed at diagnosis and throughout the duration of treatment. There is a need for an objective, quantitative biological measurement of headache pain severity. In this study, quantitative sensory testing (QST) was conducted vi...

journal_title：Brain research

authors： Nguyen RH,Ford S,Calhoun AH,Holden JK,Gracely RH,Tommerdahl M

更新日期：2013-03-01 00:00:00

abstract：:Levodopa (L-DOPA) is widely used for symptomatic management in Parkinson's disease. We recently showed that (-)-epigallocatechin-3-gallate, a tea polyphenol, not only inhibits L-DOPA methylation, but also protects against oxidative hippocampal neurodegeneration. In the present study, we sought to determine several oth...

journal_title：Brain research

authors： Kang KS,Yamabe N,Wen Y,Fukui M,Zhu BT

更新日期：2013-02-25 00:00:00

abstract：:In the present study, we characterized the evoked electrical activity from T(13) to S(2) dorsal roots (DRs) during glass probe-stimulation of the vagina-cervix-uterus junction (VCUJ) of female Wistar rats. The results showed that gentle stimulation of VCUJ evoked high-amplitude electrical activity in L(3) and L(6) DRs...

journal_title：Brain research

authors： Tovar A,Lara-Garcia M,Cruz Y,Pacheco P

更新日期：2013-02-16 00:00:00

abstract：:Microarray analysis has been used to understand how gene regulation plays a critical role in neuronal injury, survival and repair following ischemic stroke. To identify the transcriptional regulatory elements responsible for ischemia-induced gene expression, we examined gene expression profiles of rat brains following...

journal_title：Brain research

authors： Pulliam JV,Xu Z,Ford GD,Liu C,Li Y,Stovall KC,Cannon VS,Tewolde T,Moreno CS,Ford BD

更新日期：2013-02-07 00:00:00

abstract：:Visual spatial orienting of attention towards exogenous cues has been one of the attentional functions considered to be spared in ADHD. Here we present a design in which 60 (30 ADHD) children, age: 10.9±1.4, were asked to covertly orient their attention to one or two (out of four) cued locations, and search for a targ...

journal_title：Brain research

authors： Ortega R,López V,Carrasco X,Anllo-Vento L,Aboitiz F

更新日期：2013-02-01 00:00:00

abstract：:It has been confirmed that gabapentin (GBP) induced a inhibition of the voltage-gated persistent sodium current in chronically compressed dorsal root ganglion (DRG) neurons. The persistent sodium current is found in excitable DRG neurons of painful diabetic neuropathy (PDN) rats where it is mediated by tetrodotoxin (T...

journal_title：Brain research

authors： Zhang JL,Yang JP,Zhang JR,Li RQ,Wang J,Jan JJ,Zhuang Q

更新日期：2013-02-01 00:00:00